The pharmaceutical manufacturing process and critical quality attributes (CQAs) are not only needed to control tightly but also required to be protected from any vulnerability in real-time. Currently, pharmaceutical manufacturing companies are facing enormous challenges to protect their plant from possible cyberphysical security (CPS) threats. Cyber-physical security is essential not only to protect the plant from any mechanical damages but also to assure the product quality and thereby, patient safety. The quality of the pharmaceutical products can be improved significantly by implementing advanced model predictive control (MPC) systems if an appropriate cyber-physical security defense is in place.
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