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In the battle against antibiotic resistance, scientists are harnessing the potential of AMPs as a potent alternative to traditional antibiotics. As pathogens continue to evolve and resistance strategies become more sophisticated, new solutions are very crucial. Enter AMPs and their databases, an incredible approach to fight against antibiotic resistance.

The discovery of the first reported AMP, penicillin, by Alexander Fleming in the 1920s marked a significant milestone. Subsequently, gramicidin, another AMP, was discovered in Bacillus spp. in 1939 and showed effectiveness against pneumoco

Many Pharma companies in EU suffer a size problem. When revenues are below 100 M€ is extremely difficult to survive in a market where to renew the portfolio is increasingly costly, as well as to pay the regulatory demands, which grow year by year (environmental regulations, verification, wastes processing, plastics control, etc...). Additionally, the easy solution of playing in the Generics Market does not work anymore, mostly due to the devastating price erosion in major markets (France, Germany, Italy and Spain). These companies use to be a family property and their operations do not exceed

The Cannabis industry has been on a growing trend for the last few years, as many steps into the regulation and legislation of its products for medicinal and recreational use in different countries have recently changed. As examples, in April 2023 Germany announced a preliminary plan to legalize Cannabis for personal use thus allowing people to grow up to three plants at home. Mexico approved the medicinal and scientific use of Cannabis in 2017 and its recreational use in 2021. As of November 2018, physicians in the UK are legally allowed to prescribe Cannabis-based medicines (Stevens, 2018).

Cancer is considered as a common name to address a large group comprising more than 100 diseases affecting several parts of the body. All cancers show common characteristics such as the uncontrolled growth and proliferation of abnormal cells, infiltrating and spreading to different tissues and organs throughout the body, and destroying the normal cells and tissues. Cancer can begin in the epithelial tissue and is known as carcinomas, and when it begins in the connective or supportive tissue, they are called sarcomas. The blood cancers are known as leukemias, and when it begins in the plasma c

Bioinformatics is a multidisciplinary field that harnesses the power of information technology, mathematics, statistics, machine learning, and even quantum physics to solve complex biological problems. Its primary goal is to make sense of vast biological datasets by providing algorithms and methods for data cataloging, visualisation, annotation, interpretation, and more. With the advent of Next-Generation Sequencing (NGS) technologies, the field has witnessed an explosion of computational tools and databases that have accelerated research in unprecedented ways.

In the age of information an

India is rapidly emerging as a global hub for clinical research, with many international pharmaceutical companies and research organisations choosing the country as a site for their clinical trials. However, the majority of clinical research is conducted in Tier-1 cities such as Mumbai, Delhi, and Bangalore, with much less attention paid to Tier-2 and Tier-3 cities in South India.

There are several reasons why Tier-2 and Tier-3 cities in South India are not included in clinical research. One of the main reasons is the lack of infrastructure and resources required for conducting clinical tr

Regulatory medical writing is a highly complex task and requires expertise. There are various challenges that medical writers face every day while creating documents required for submissions to competent Health Authorities (HAs). One of the major challenges here is the time required for the entire medical writing process, from the first draft to the final submissions-ready draft. If some of the steps in this process are automated, it will save medical writers a lot of time and reduce the turnaround time.

Quantum computing is a field that uses quantum mechanics to solve complex problems faster than classical computers. It emerged in the 1980s when it was discovered that certain computational problems could be tackled more efficiently with quantum algorithms than with their classical counterparts. Unlike classical computers that use bits, which can only be 1 or 0, quantum computing involves qubits that can exist in a multidimensional state. The power of quantum computers grows exponentially with more qubits, while classical computers that add more bits can increase power only linearly. Quantum

Decentralized clinical trials (DCTs) leads with a premise to leverage technology to transform the traditional clinical trials model. Incorporating digital tools, telemedicine, and real-world data, DCTs enhance flexibility, accessibility, and participant-centricity. Such a promising alternative addresses inefficiencies, high costs, and limited diversity, revolutionizing the landscape of medical research.

Traditional clinical trials have long served as the cornerstone of medical research, providing essential evidence for evaluating the safety and efficacy of new interventions. However, these

Artificial intelligence is a field of engineering and science that focus on making intelligent machines. Artificial intelligence is a top technology that is reshaping the pharmaceutical industry's future. For ages, the pharmaceutical industry has been developing cures and treatments. Traditionally, medication design and manufacture took many years, extensive clinical studies, and sky-high prices.This has been changing with the advancement of 21st-century technology. We will see different drug designs, manufacturing, and clinical trials in the future.

Natural Language Processing (NLP), Mach

Medicine is the testament to the virtue of human innovation - a collective desire to reduce the burden of disease and an ever evolving journey to enhance the quality of human health. The origin of medicines can be traced back to ancient times when human began to use the natural resources to treat injuries and illness. Highly developed and documented evidences of medicinal practices comes from the world’s most ancient civilisations such as Egypt, India, China and Greece1. Traditional Chinese medicine2, which dates back more than 2,500 years, used a combination of herbs, acupuncture, and other

Clinical research technology platforms have also emerged, providing participant-facing apps and websites where you can build in or interface with some or all the previously mentioned solutions, as well as expanding to other research-related activities such as virtual training, electronic informed consent form (eICF), participant recruitment, engagement, visit reminders and concierges, etc. Implementing these platforms, the individual participant is given an even more active role in their own research journey, as they are responsible to enter their own subjective data directly into the designa

Artificial Intelligence (AI) and machine learning-based technologies have the potential to transform healthcare because they offer new and important insights derived from the vast amount of data generated during the delivery of healthcare every day. The capacity of AI to learn from real-world feedback and improve its performance makes this technology uniquely suited as Software as a Medical Device (SaMD) and is responsible for it being a rapidly expanding area of research and development. Clinical pharmacy practice may undergo major change due to the implementation of this technology. The cha

Globally, the outsourcing of services for drug development and commercialisation is increasing. Regulatory services are often included in this, and regulatory activities are increasingly the subject of specific, dedicated FSP (functional services partnership) projects. This article overviews a number of the more common models, including cost models, that can be deployed for the outsourcing of regulatory services. We assessed the appropriate criteria and advantages of these models, illustrating with examples from our experience. Interestingly, over the life of a single project, different model

Pharma 4.0, an application of Industry 4.0 concepts in the pharmaceutical industry, aims to enhance manufacturing efficiency, product quality, and consistency. It faces challenges in areas like artificial intelligence, material traceability, optimization, process control, cyber-physical security, and data management due to the complexity involved. However, by incorporating artificial intelligence and advanced model predictive control with robust cyber-physical security measures, predictive capabilities and product quality can be significantly improved. This work focuses on implementing seven

The biopharmaceutical industry operates under strict regulations, and effective supply chain management is crucial for patient safety and timely access to treatments. The biopharmaceutical supply chain is responsible for ensuring efficient and secure delivery of drugs and vaccines while maintaining product quality. Challenges such as compliance, risk management, and technology adoption have emerged in recent years. Cold chain management, monitoring technologies, and new regulations like DSCSA and FMD have impacted the industry. Adhering to trends and regulations, including blockchain and arti

The principles of Humane Experimental Technique has resulted in 3Rs concept: Replacement, Reduction and Refinement of animal tests. The number of animals used for both preclinical and quality control is thought to be reduced to zero if vaccines are better characterised while allowing testings by a set of in vitro methods rather than in vivo scenarios. The in vitro methods to detect safety related to potency of vaccines can employ alternative platforms like that of human derived cell/tissue based surrogate systems - The humane technique facilitating increased control of critical stepsin produc

The life sciences sector has become increasingly popular given the ongoing global health crisis, putting the spotlight firmly on the need for greater medical care and infrastructure. Implementation of tech solutions to improve existing health infrastructure has also become a trend and one likely to continue as current health and economic challenges due to COVID-19 will see digital health companies playing a more important role in corporate and national growthThe life sciences sector continues to see a multitude of deals involving complex deal structures, from special purpose acquisition compa

It’s been nearly two years since the outbreak of COVID-19 began and we’re still in the midst of enormous disruptions to the world’s economies, businesses, education, and people’s lives. The pharmaceutical industry has been particularly disrupted. Previously, pharma companies suffered from a bad reputation. But following the emergence of the pandemic, they were thrown into the spotlight, suddenly having an important voice on the health of the world. Leaders in the pharma space were on the front cover of every newspaper and magazine not because of scandal, but because of the lifesaving treatmen

The Global Biosimilars Market is estimated to reach US$240 billion by 2030, with the Indian market at US$35 billion. The considerable increase in reference products, with the USFDA adding 90 molecules and India approving 70 biosimilars, promises to usher in further growth. The Biopharma industry seems keen on investing in the biosimilar market with a focus on improving healthcare and health care costs for diseases of interest like COVID-19, cancer, immunologic diseases, and diabetes. This is evident in the projected growth of the oncology biosimilar market at 17 per cent CAGR, and the growing